"There is no way back from a multicultural Europe. Neither to a Christian Europe, nor to the world of national cultures," Orban added.
He insisted that migration needs to be addressed seriously.
"If we make a mistake now, it will be forever," Orban, 52, said.
Orban was recently criticised for a questionnaire sent out to Hungarian citizens that linked migrants and asylum seekers with terrorism, which EU Commission vice president Frans Timmersmans slammed as "malicious and wrong".
Orban is a fierce opponent of the migration plan put forward by the Commission to evenly distribute asylum seekers among member states, a policy which he called "mad and unfair".